COVID19 Vaccine Update

December 8, 2020

The future is here and the future is now! The end of 2020 and soon to be beginning of 2021 is looking up as the FDA has confirmed today the safety data and efficacy of Pfizer/BioNTech's mRNA vaccine. With the UK already beginning mass inoculations as of today, I wanted to provide you all with the most up to date information consolidated in one blog post. My sources include CDC, WHO, FDA, NYTimes, and CNN as well as all those embedded in hyperlinks.


First thing's first, let's break down what the COVID19 vaccine is, keeping in mind the two front-runners are Pfizer/BioNTech and Moderna. Both of these are mRNA vaccines. Not all of the vaccines under development are mRNA vaccines. Additionally, none of the COVID19 vaccines under development in the US use the live virus.

I really like Dr. Mike Natter's simplified drawing of this (be sure to scroll through):




While the mRNA vaccine involves a new approach to immunization, the technology is not new. In fact, using mRNA was discovered over 30 years ago and the design was implemented in the 2003 SARS and 2013 MERS outbreaks. However, at that time, due to lack of funding, the trials were unable to finish completion. Despite this, the research was still helpful when it came time to develop a vaccine to fight COVID19. There were similarities between SARS-CoV-2 (the virus that causes COVID19) and MERS. When asked if the COVID19 vaccine was rushed, one has to take into account how far science, medicine, and technology has progressed, which has allowed for such expedience and efficiency. "[T]he speed of these developments...is impressive, owing to both the relentless work of the scientists and the unprecedented demand of the circumstances," (Race for a COVID-19 Vaccine).

For additional information, check out public health expert and pediatrician Dr. Risa Hoshino's post below:


With the widespread reach of social media comes the potential for misinformation. A few things that I want to make sure are clear in regards to what the vaccine is not:


The concept of infertility is an important one I want to highlight. There is a statement going around claiming that the spike protein used in the mRNA vaccine, which can be found on the virus causing COVID19 shares a sequence of 5 to 6 amino acids (out of over a thousand amino acids) also found in a placental protein known as syncytin-1. The assertion that this could lead to infertility in women has little to no basis. Additionally, female patients who have previously been infected with COVID19 develop antibodies naturally to this spike protein. Tens of thousands of women have been able to conceive after infection. One more thing to add - no fetal cell cultures are required to manufacture the vaccine.

Dr. Jesse O'Shea has a great tutorial with more information about this as well as the question of infertility in men due to COVID19 infection:





I hope this gave you all a concise summary. The first phase plan is to offer the vaccine voluntarily. As soon as it is approved by the FDA and available, I trust the science, the research, and our healthcare experts. When offered to me, I plan to be first in line to receive it. Medicine is all about weighing risk vs. benefit and to me, the benefit of being protected from COVID19 outweighs any risk, especially given the already established safety and efficacy of the vaccine. Let me know if you have any questions.


 

Spread Thanks Not Viruses

November 21, 2020

My latest post on Instagram talks about Pandemic Fatigue - the feeling of becoming desensitized to the news, jaded to the world, and tired of the COVID19 crisis. By self-isolating in our own 6-foot radius bubble, we are prone to fatigue, irritability, depression, mood swings, and more. I provided a full list of ways to cope with this in my post below.

In March, many of us healthcare professionals were praised as heroes. However, since then, we have been subjected to unfounded criticisms, baseless lies, and false accusations. Attempts have been made by the news to discredit our credentials and devalue our efforts as we continue to work tirelessly to prevent the spread of infection.

Despite this, I have received so many overwhelmingly positive responses from followers, friends, and family. The support has drowned out all the negative comments and backlash as well as bolstered our confidence that we can and will fight this disease. Pfizer and BioNTech both filed with the FDA for emergency use authorization of their COVID19 vaccine candidate. This brings hope and promise to what has felt like a neverending lockdown but does not change our current situation. We must continue adhering to safety measures including wearing a mask, social distancing, and washing our hands. The CDC has released a statement advising against traveling for the holidays.


Healthcare systems are already strained with several at maximum capacity. Words like "intubation" and "ventilators" are now common headlines on news outlets. Even with being household names, the majority of the general public does not understand the gravity of what these medical terms mean. When COVID19 cases are severe enough, patients are admitted to the hospital, and, in some cases, intensive care units, where they can be closely monitored.





If these patients cannot maintain their airway, further intervention is warranted. This includes intubation and ventilation. Their oxygen levels are dropping so low (termed hypoxia) and/or they are unable to eliminate carbon dioxide effectively. As a result, a tube is placed down their windpipe (trachea), which is hooked up to a machine (ventilator) used to pump air into their lungs.


This in and of itself can leave patients prone to additional complications, from hospital-acquired pneumonia, blood clots, delirium, deconditioning/severe weakness as muscles atrophy from disuse, and more. In some cases, patients require an additional intervention called ECMO (Extracorporeal Membrane Oxygenation), which can help replace the function of the heart and lungs if necessary. With limited resources, including ventilators, hospitals will soon be unable to support the rising number of cases let alone treat patients for other medical conditions.
That is why we as healthcare workers are not just asking, we are begging for people to protect their loved ones this holiday season by not traveling. My colleagues and I have already had to make so many sacrifices this year, including not seeing our friends or family. But together we can conquer this.


This is not the year to get everything we want, it is the year to appreciate everything we have. Give thanks to one another, especially to the front-line workers who are making sacrifices every day. Acknowledge the strength we have as a community and as a nation today in order to shape a better, safer, and healthier tomorrow.

Path to Becoming a DO

October 21, 2020

It’s a marathon, not a sprint. I say this to my patients and medical students all the time. Everyone’s journey to medical school is unique - some matriculate straight from college, others take time off or have an entire career before deciding on medicine (in my medical school class we had a nurse, a lawyer, and an opera singer). Whatever path you’re on, keep a steady pace, don’t lose sight of what’s ahead, and know that you will get to the finish line.

I chose DO over MD when it came to applying for medical school because I admired the holistic philosophy and osteopathic approach. I liked the idea of having osteopathic manipulative medicine as an extra alternative tool to offer patients. I also shadowed a DO who inspired me to go to his medical school - the way he interacted with his patients, getting down at eye level, taking a seat to focus on them and not the computer or documentation, how he knew each patient's story made me aspire to be like him. And you can too! Here is a simple outline of how to become a DO. Plus you can keep scrolling to learn more about my own path:

  • 4 years of undergraduate in any major as long as you complete pre-med requirements.
    • I earned a B.S. in Biology and B.A. in Classics
    • I loved combining the arts and sciences and was even able to travel abroad three times (London, Italy, and the Netherlands).
    • Learning Greek and Latin helped me with medical terminology as well.
    • One thing my dad taught me was not to judge a school (whether college or medical school) by its name but by the curriculum and the professors - learn about their background and teaching styles, what the course structure is for however many years. Get a feel for if it offers what you're looking for and if it can help you achieve your future goals.
  • Get involved in extracurriculars like clubs/organizations, volunteering, shadowing, and research.
    • I was an EMT, as well as an ER volunteer, research assistant for several labs, and more.
    • I shadowed DOs and MDs during college for early clinical exposure.
    • These experiences introduced me to patient care, which helped solidify my desire to become a doctor.
  • Take MCAT exam, apply, interview, get accepted to medical school. I summarized this in one line but, of course, it’s not that easy.
    • I took the MCATs twice to work on improving my score. Fun fact, I applied to medical school while I was doing research in the Netherlands...talk about a challenge - coordinating all the paperwork and making phone calls from another country is not easy, especially with time zone differences.
    • I was accepted my first time applying but I know some incredible doctors who didn’t get in until their 2nd or 3rd cycle.
    • As I said in the beginning, not everyone goes to medical school right away and that’s NORMAL. I matriculated straight out of college but I had classmates who took time off or had an entire career before deciding on medicine - one was a nurse, one was a lawyer, and one was even an opera singer. 
    • If you want it badly enough, you will succeed.
  • 4 years medical school with OMM (Osteopathic Manipulative Medicine) courses.
    • This is broken down into two years of medical knowledge (think - hitting the books) and two years of clinical rotations (where you are actually working in clinics/hospitals).
    • Don’t forget to get involved in clubs/organizations, research, and volunteer opportunities. That’s right - on top of endless studying, exams, and reviews you want to keep building experiences that will help you find and match into your future specialty.
  • Take COMLEX Levels 1, 2, and 3 (+/- USMLE)
    • These are the medical school board exams you need to pass as a DO (one of which includes a clinical skills portion).
    • I also took USMLE (specific for allopathic or MD) but now that residency programs have merged, it’s not really necessary and IMO it’s a money grab.
  • Apply, interview, and match into residency (3-7 years on average +/- fellowship).
    • By now you have graduated from medical school and have earned the title of "Doctor" but are still in need of refining your clinical and diagnostic skills. This involves additional training in your chosen specialty.
    • Note that not everyone goes into residency right away or at all - it depends on how you want to use the DO degree. I knew some doctors who chose to work in research, quality improvement/medical startups, and pharmaceutical industries with their knowledge rather than go into clinical practice.
    • The match process itself is weirdly kind of similar to a dating app. More info in future posts. I ended up in Philadelphia at one of my top choices for Physical Medicine and Rehabilitation.
  • Once you’ve graduated from residency you have the option to further specialize in fellowship. For example, I’m doing Cancer Rehabilitation, helping medically manage and optimize patients' functionality and quality of life before, during, and after cancer treatments.

Finally, this time next year I will have reached the metaphorical “finish line” and be able to call myself an attending! But that doesn't mean it's over. A doctor is a lifelong learner, helper, and healer.

Did I know I wanted to go into PM&R when I started medical school? No.

Did I know I wanted to be a Cancer Rehabilitation doctor when I started residency? No.

Did I know I wanted to be a great doctor, inspire my patients (and you) to be their best selves? Yes, and that’s what matters. All the rest comes with time, patience, and a little networking over Butterbeer (at least that's how I ended up learning about Cancer Rehabilitation).

Questions? Feel free to DM me on IG (@doctor.cole), send me an e-mail, or leave a comment below!

What is OMM?

October 8, 2020


The news including The Rachel Maddow Show, CNN, and NPR have yet to apologize for attempting to turn DOs (Doctors of Osteopathic Medicine) into a political smear campaign. So let’s take a moment to educate them and the rest of the world on a few key terms including OMM and the differences between DOs and Osteopaths.


OMM, also known as Osteopathic Manipulative Medicine or OMT for Osteopathic Manipulative Treatment, is an additional skill we as DOs have to offer patients literally at our fingertips. This set of hands-on techniques is used to assess for and treat structural and functional issues related to the muscles, tissues, joints, and bones of the body. These include soft tissue and myofascial release (reminiscent of massage therapy) as well as high-velocity low amplitude and articulatory methods. OMM is similar to a Chiropractor's manipulations but with a different approach and understanding of the anatomy and musculoskeletal system.


It helps promote movement of blood flow and lymphatic fluids, restore muscle and tissue imbalance, and adjust misalignments. It can complement or in some cases replace medicine and surgery as it has been used for common disorders like asthma, carpal tunnel syndrome, muscle and joint pain, sinus problems, and migraines. Learn more
HERE.


Often, patients experiencing muscle pain or tenderness, restriction in their range of motion, or asymmetry find relief from OMM. Learn more HERE.

Osteopaths are also trained in these maneuvers. However, osteopaths differ from doctors of osteopathic medicine in that they are not trained to prescribe or practice medicine. Osteopaths are more commonly found outside the US.



And finally, the doctor for the next President of the United States is a DO. With that in mind, to all the countries (speaking to you, Canada) and celebrities (Cher and Bess Kalb) trying to discredit DOs, please stay in your lane.


Thank you for reading. Please pass this on to those who may not be informed. And ask your doctor if OMM is right for you - never underestimate the healing power of touch.

DO vs MD: What's The Difference?

October 6, 2020

Photo Credit: shootwithcass

DOs may be less common but we are not less than MDs. It takes years to receive the education and training needed to be a US physician but minutes to destroy our reputation. The media is capitalizing on the healthcare crisis and trying to discredit DOs because of the current political arena. CNN and NPR implied Dr. Sean Conley was less qualified because he was a "non-MD" or DO (Doctor of Osteopathic Medicine - a field of medicine whose founding father was an MD). They thank us one minute then defame us the next.

We must #stoptheignorance and educate the public. Despite making up 11% of the nation’s doctors, a number that is quickly growing, we are just as qualified to practice medicine as MDs and adhere to the same standards of care. We are working tirelessly during this pandemic to treat patients, not TV personalities.

As an osteopathic physician (otherwise known as a DO), we receive the same education as our allopathic or MD counterparts with an additional 250+ hours of training on osteopathic manipulative treatments. Being able to offer an alternative or adjunct treatment to patients gives us a powerful tool right at our fingertips. The following is a list of key differences and similarities between DO and MD degrees:

Osteopathic manipulative medicine (OMM - also known as OMT for Osteopathic Manipulative Treatment) is a set of hands-on techniques used to assess for and treat tissue texture changes, asymmetry, restriction, and tenderness. These techniques include soft tissue and myofascial release (reminiscent of massage therapy) as well as high-velocity low amplitude and articulatory methods. This is similar to a Chiropractor but with a different approach and understanding of the anatomy and musculoskeletal system. We utilize different characteristics and body mechanics to manifest structural changes through positioning, palpating, and balancing planes of motion. These practices can be performed directly into the barrier or indirectly into a position of ease. They can be done actively with the patient contracting their muscles or passively with the muscles relaxed. Learn more HERE.

While residency programs have merged and we train side by side with MDs, the holistic philosophy of our schooling remains ingrained in our approach to patient care. We promote the body’s natural tendencies toward self-healing, self-regulation, and health. We focus on treating the patient as a whole and not just the disease. Below is a list of our four Osteopathic Tenets.

How can YOU help?  Spread this information, follow other DOs on Instagram or other social media platforms, and tell your friends/family/followers. Disseminate and educate, don't discriminate. Check out the AOA for more information.

AmorSui's Antimicrobial Gloves

September 22, 2020

Coming Fall 2020: AmorSui Alice Hamilton Antimicrobial Gloves

Caring for patients extends beyond the hospital and clinic. Recognizing this need as a doctor, commuter, fitness enthusiast, and city dweller, I wanted to offer you all a safe, sustainable, and effective way to decrease your risk of infection. This past year I have been working closely with clothing company AmorSui (Latin for "Self-Love") to turn my idea of antimicrobial gloves into a reality. The Silvadur fabric technology we used is designed to optimize antifungal and antibacterial properties, providing an added layer of protection for your health. 

Shop AmorSui and use code DOCTORCOLE for 10% off $100 or more

With a team of empowering women at AmorSui we knew it was only right to name this product after a strong female figure in STEM (Science, Technology, Engineering, and Mathematics). The role model we chose led the crusade against infectious disease as a doctor and researcher. Today of all days marks not only the first day of fall but also the anniversary of her passing, for which we pay tribute to her legacy and introduce the official name for these gloves:

Alice Hamilton

Who is Alice Hamilton?

She is a historical icon for women empowerment and the advancement of medicine. Dr. Hamilton was an American physician, research scientist, humanitarian, as well as social and political activist. Best known for pioneering the field of epidemiology, she was a leading expert in occupational health and safety. From studying typhus to industrial toxins, she championed the protection of the poor and working class, setting "precedents for civic responsibility for public health," (Gore, 2019). Many of her recommendations are now commonly implemented safety standards in the workplace.

In 1919, she became the first woman appointed to the faculty of Harvard University but this too did not come without its own challenges and stipulations. She had to fight for her voice in a time when women were silenced from public speaking. Her voice has carried through along with her achievements, inspiring other female leaders like Eleanor Roosevelt. Despite having passed away September 22, 1970 at 101 years old, Dr. Alice Hamilton's legacy lives on in our new antimicrobial gloves, continuing to make a difference and keep the public safe at work, at home, and in the community. 


These Alice Hamilton Gloves are aptly named given the team of incredible women who brought my idea to life including:

Beau Wangtrakuldee, PhD - founder and CEO of AmorSui

Beau Wangtrakuldee's burns from a laboratory accident in 2014 could have been much worse, she said, but were scary enough to influence her to develop a clothing line for women that is both protective and fashionable.

Dr. Wangtrakuldee had the idea for AmorSui clothing after sustaining a chemical injury while in her doctoral training program in Chemistry. She started this company in order to offer women in STEM a line of apparel that combines function with fashion, incorporating antimicrobial, chemical, and fire-resistant fabrics with safety and sustainability in mind.

Victoria Wright - Philadelphia Fashion Designer (@victoriawrightofficial)

Victoria Wright

Born and raised in Bucks County, Victoria Wright knew from an early age that she was going to be a fashion designer. She studied in New York City at Parsons the New School for Design as well as Philadelphia’s Moore College of Art and Design. Upon completing various internships and freelancing for companies such as Rebecca Taylor, Urban Outfitter’s, and Club Monaco, Victoria began to visualize her own brand and joined the Philadelphia Fashion Incubator. With over 10 years of experience in design, product development, and production, and a passion for bringing functional and beautiful garments to women worldwide, Victoria now has joined the AmorSui team as Product Development and Production Manager. 

Katie Sue Nicklos - NYC's couture glove maker

Wing + Weft GLOVES, Inc

Wing & Weft Gloves, formerly Lacrasia Gloves, has been providing a singular service for clients across the nation since 1973; a one-stop “mom and pop” shop for custom and small batch production gloves made in NYC’s Garment Center. A unicorn business in this world of fast-fashion and overseas manufacturing, Wing & Weft Gloves is led by Katie Sue Nicklos who holds the legacy of the only glove shop remaining in the USA with a direct legacy to Gloversville, New York. Their client list is vast, having made gloves for celebrities (Prince, Lady Gaga, Madonna), for Broadway (Moulin Rouge, Frozen, Rent), for tv (The Marvelous Mrs. Maisel, Dickinson, The Boys), for film (The Irishman, Little Women), for runway (Calvin Klien, Christian Siriano, Christian Cowan), for drag queens (Sasha Velour, Monet XChange, RuPaul), for debutantes and for first ladies (Jackie Kennedy, Michelle Obama). The talented craftspeople of Wing & Weft Gloves continue to do something extraordinary every day: keep a vanishing craft alive in the heart of New York City. They glove you!

Stay tuned for the official product launch of the Alice Hamilton gloves - coming this Fall!

Reference:

Gore, Karenna. (2019, August 29). The Remarkable Life of the First Woman on the Harvard Faculty. 

How To Preserve Your Memory

August 26, 2020

A friend of mine recently asked me how I stay motivated to workout, especially during quarantine - how to avoid the "Quarantine 15." As important as exercise is for staying in shape physically, it is just as important for you to stay in shape mentally and not just when it comes to handling stress, anxiety, and/or emotions. Research has found that there is a hormone released during exercise called Irisin, which may have beneficial effects including weight loss, thermoregulation, and neuro-cognitive protection. This includes protecting your memories in hopes of fighting neurodegenerative diseases like Alzheimer's dementia through synaptic plasticity (strengthening the pattern of communication between neurons) and neurogenesis (forming new neurons). Recognizing the impact that fitness has on not just the body but the brain motivates me to stay active and holds me accountable to protect my memories along with all that I have learned (medical school tuition isn't cheap).


Fun fact: Irisin comes from the name Iris, the Greek goddess known as the messenger of the gods. Can you tell I was a Classics major in college? Initially discovered in the skeletal muscle tissue of mice, it is a cleavage protein also found in humans derived from fibronectin type III domain 5 (FNDC5). This means when you exercise, FNDC5 is converted to irisin. In terms of weight loss, irisin has been shown to influence the browning of adipose (fat) cells.


When you think of fat, there are two main types: white and brown (there is also visceral and subcutaneous but we won't get into that). White fat is responsible for the standard large deposits that store energy and produce hormones but also can lead to obesity. In contrast, brown fat has smaller "droplets" with large amounts of mitochondria (think of these as engines), meaning this tissue can generate a LOT of energy. For us, this comes through as heat. Thus, brown fat is used to keep us warm, so, in addition to decreasing white fat, irisin has a thermoregulation benefit (Irisin: An Overview). Other studies have found irisin improves insulin sensitivity and glucose metabolism, which may play a role in preventing metabolic syndrome and diabetes (Kim & Song, 2018).

While exercise is known to improve cognitive function, especially in neurodegenerative diseases such as Alzheimer's and Parkinson's, understanding how has been and continues to be under investigation. From increasing blood flow to the hippocampus, a part of the brain that helps form new memories, to synaptic plasticity, neurogenesis and decreasing neuro-inflammation, physical activity improves outcomes for the mind as well as the body (Kim & Song, 2018). "The beneficial effects of exercise seem to depend on crosstalk between muscles and nervous tissue through the increased release of muscle irisin during exercise," (Bristot, 2019). This crosstalk plays into memory and is most closely associated with endurance and aerobic routines. "Irisin enhances brain function by modulating neurotransmitter secretion," (Kim & Song, 2018; Mattson, 2012). Because of its brain boosting capabilities, irisin has been purported to be an agent for fighting dementia and memory impairment after being studied in mouse models with Alzheimer's. So, the best way to protect your memory? Well, if you have time to read this blog post, it means you have time to exercise - get out there and get moving!

References:

Bristot, V., et al. "The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain." Fronteirs in Neuroscience. 2019 March. Retrieved August 26, 2020 from https://www.researchgate.net/publication/332074712_The_Role_of_PGC-1aUCP2_Signaling_in_the_Beneficial_Effects_of_Physical_Exercise_on_the_Brain.

"Irisin: An Overview." ScienceDirect. Retrieved August 26, 2020 from https://www.sciencedirect.com/topics/neuroscience/irisin.

Kim, O. & Song, J. "The Role of Irisin in Alzheimer’s Disease." Journal of Clinical Medicine. 2018 Nov. Retrieved August 26, 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262319/.

Lourenco, M., et al. "Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature. 2019 Jan. Retrieved August 26, 2020 from https://www.nature.com/articles/s41591-018-0275-.

Mattson M.P. "Energy intake and exercise as determinants of brain health and vulnerability to injury and disease." Cell Metabolism. 2012;16:706–722. doi: 10.1016/j.cmet.2012.08.012. Retrieved August 26, 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518570/.

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